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Hoxd3tm1Mrc
Targeted Allele Detail
Summary
Symbol: Hoxd3tm1Mrc
Name: homeobox D3; targeted mutation 1, Mario R Capecchi
MGI ID: MGI:1857959
Synonyms: Hoxd3-
Gene: Hoxd3  Location: Chr2:74542337-74578615 bp, + strand  Genetic Position: Chr2, 44.13 cM, cytoband C2
Alliance: Hoxd3tm1Mrc page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:15678
Parent Cell Line:  CC1.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
    A neomycin cassette was inserted into sequences encoding the second helix of the homeobox domain. (J:15678)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
In Structures Affected by this Mutation: 7 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd3 Mutation:  13 strains or lines available
Notes
Homozygous mutant mice have anterior homeotic transformations of cervical vertebrae I and II, the atlas and axis vertebrae. The atlas is fused with the skull, while the axis is altered to an "atlas-like" conformation (J:15678). Although null mutations of Hoxd3 and its paralog, Hoxa3, cause no defects in common, they interact in double mutant mice, the atlas being completely deleted (J:19447).
References
Original:  J:15678 Condie BG, et al., Mice homozygous for a targeted disruption of Hoxd-3 (Hox-4.1) exhibit anterior transformations of the first and second cervical vertebrae, the atlas and the axis. Development. 1993 Nov;119(3):579-95
All:  7 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory