Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Tcirg1tm1Ypl Name: T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3; targeted mutation 1, Yi Ping Li MGI ID: MGI:1857950 Synonyms: Atp6i- Gene: Tcirg1  Location: Chr19:3946050-3957133 bp, - strand  Genetic Position: Chr19, 3.62 cM Alliance: Tcirg1tm1Ypl page

Snx10tm1a(EUCOMM)Raba/Snx10tm1a(EUCOMM)Raba and Tcirg1tm1Ypl/Tcirg1tm1Ypl mice show osteopetrorickets Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:58795
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     A PGK-neomycin resistance cassette replaced 3.0kb of sequence including exons 2-5. (J:58795) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcirg1 Mutation:	35 strains or lines available

Original:	J:58795 Li YP, et al., Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet. 1999 Dec;23(4):447-51
All:	4 reference(s)