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Notch1tm1Grid
Targeted Allele Detail
Summary
Symbol: Notch1tm1Grid
Name: notch 1; targeted mutation 1, Tom Gridley
MGI ID: MGI:1857877
Synonyms: Notch1-, Notch1in32
Gene: Notch1  Location: Chr2:26347914-26393834 bp, - strand  Genetic Position: Chr2, 18.91 cM
Alliance: Notch1tm1Grid page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17509
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsInsertion of a neomycin cassette into an exon encoding EGF repeat 32, disrupting the reading frame of the protein. (J:17509)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 15 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 8 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Notch1 Mutation:  115 strains or lines available
References
Original:  J:17509 Swiatek PJ, et al., Notch1 is essential for postimplantation development in mice. Genes Dev. 1994 Mar 15;8(6):707-19
All:  26 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory