Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Hoxa1tm1Mrc
Name:	homeobox A1; targeted mutation 1, Mario R Capecchi
MGI ID:	MGI:1857840
Synonyms:	Hox-1.6-, Hoxa1-
Gene:	Hoxa1  Location: Chr6:52132573-52135299 bp, - strand  Genetic Position: Chr6, 25.4 cM
Alliance:	Hoxa1tm1Mrc page

Germline Transmission:	Earliest citation of germline transmission: J:1776
Parent Cell Line:	CC1.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin cassette was inserted into sequences encoding the homeodomain. Note that this allele disrupts expression of only one of two alternatively spliced transcripts. (J:1776) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	145 assay results
In Structures Affected by this Mutation:	25 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxa1 Mutation:	14 strains or lines available

Original:	J:1776 Chisaka O, et al., Developmental defects of the ear, cranial nerves and hindbrain resulting from targeted disruption of the mouse homeobox gene Hox-1.6 [see comments]. Nature. 1992 Feb 6;355(6360):516-20
All:	4 reference(s)