Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Acvr2btm1Enl
Name:	activin receptor IIB; targeted mutation 1, En Li
MGI ID:	MGI:1857709
Synonyms:	ActRIIB-, Acvr2b-, IIB-KO
Gene:	Acvr2b  Location: Chr9:119231184-119264061 bp, + strand  Genetic Position: Chr9, 71.33 cM
Alliance:	Acvr2btm1Enl page

Germline Transmission:	Earliest citation of germline transmission: J:42018
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.4kb genomic fragment containing two exons encoding the transmembrane and part of the kinase domains was replaced by a neomycin resistance cassette. (J:42018)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	83 assay results
In Structures Affected by this Mutation:	14 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acvr2b Mutation:	27 strains or lines available

Original:	J:42018 Oh SP, et al., The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse. Genes Dev. 1997 Jul 15;11(14):1812-26
All:	16 reference(s)