Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rac2tm1Mddw
Name:	Rac family small GTPase 2; targeted mutation 1, Mary C Dinauer and David A Williams
MGI ID:	MGI:1857701
Synonyms:	rac2-, Rac2tm1Daw
Gene:	Rac2  Location: Chr15:78443369-78456983 bp, - strand  Genetic Position: Chr15, 37.57 cM
Alliance:	Rac2tm1Mddw page

Germline Transmission:	Earliest citation of germline transmission: J:53362
Parent Cell Line:	CCE/EK.CCE (ES Cell)
Strain of Origin:	129S/SvEv-Gpi1c

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced a genomic fragment containing exon 1, which encodes the translational initiation site and part of the GTP-binding domain. Northern blot and RT-PCR analysis demonstrated that no transcripts were detectable in total RNA derived from neutrophils or lymphocytes in homozygous mice. Western blot analysis confirmed an absence of protein produced from this allele in peritoneal exudate cells from homozygous mice. (J:53362)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rac2 Mutation:	17 strains or lines available

Original:	J:53362 Roberts AW, et al., Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense. Immunity. 1999 Feb;10(2):183-96
All:	76 reference(s)