Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Il2rgtm1Wjl
Name:	interleukin 2 receptor, gamma chain; targeted mutation 1, Warren J Leonard
MGI ID:	MGI:1857455
Synonyms:	CD132-, gammac-, gc-, IL2Rgammanull, Il2rgtm1Wjll, [KO]gammac
Gene:	Il2rg  Location: ChrX:100307991-100311861 bp, - strand  Genetic Position: ChrX, 43.9 cM
Alliance:	Il2rgtm1Wjl page

Germline Transmission:	Earliest citation of germline transmission: J:24117
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin resistance cassette replaced part of exon 3 and all of exons 4 - 8 of the gene, resulting in the loss of most of the extracellular domain and all of the transmembrane and cytoplasmic domains of the protein. (J:24117)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 77 strains available      Cell Lines: 0 lines available
Carrying any Il2rg Mutation:	168 strains or lines available

Original:	J:24117 Cao X, et al., Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity. 1995 Mar;2(3):223-38
All:	481 reference(s)