Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Wnt4tm1Amc
Name:	wingless-type MMTV integration site family, member 4; targeted mutation 1, Andrew P McMahon
MGI ID:	MGI:1857453
Synonyms:	Wnt-4-, Wnt4n
Gene:	Wnt4  Location: Chr4:137004946-137026812 bp, + strand  Genetic Position: Chr4, 69.8 cM
Alliance:	Wnt4tm1Amc page

Germline Transmission:	Earliest citation of germline transmission: J:21884
Parent Cell Line:	CJ7 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 3, encoding amino acids 106 through 196, was replaced by a PGK-neo cassette. The occasional expression of the targeted locus was observed in poorly developed aggregates in the kidneys of homozygous mutant mice via in situ hybridization. Expression was unaltered in the central nervous system and mesonephric mesenchyme. (J:21884) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	191 assay results 6 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Wnt4 Mutation:	20 strains or lines available

Original:	J:21884 Stark K, et al., Epithelial transformation of metanephric mesenchyme in the developing kidney regulated by Wnt-4. Nature. 1994 Dec 15;372(6507):679-83
All:	65 reference(s)