Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Rbl1tm1Tyj
Name:	RB transcriptional corepressor like 1; targeted mutation 1, Tyler Jacks
MGI ID:	MGI:1857448
Synonyms:	p107-
Gene:	Rbl1  Location: Chr2:156987813-157046454 bp, - strand  Genetic Position: Chr2, 78.05 cM
Alliance:	Rbl1tm1Tyj page

Germline Transmission:	Earliest citation of germline transmission: J:34058
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A PGK-neomycin cassette replaced sequences in exon 1 and a downstream intron of the Rbl1 gene. The authors predict that the mutant allele will synthesize only the first 22 amino acids of the wild-type protein. RBL1 protein was not detected in embryonic fibroblasts derived from homozygous mutant mice, or in homozygous mutant E18 embryos. Rbl1 transcript was not detected in homozygous mutant E18 embryos. (J:34058)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	160 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

List all tumor models in MMHCdb carrying Rbl1tm1Tyj

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rbl1 Mutation:	60 strains or lines available

Original:	J:34058 Lee MH, et al., Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 1996 Jul 1;10(13):1621-32
All:	62 reference(s)