Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Emx1tm1Jlr
Name:	empty spiracles homeobox 1; targeted mutation 1, John Rubenstein
MGI ID:	MGI:1857433
Synonyms:	Emx-1-, Emx1null
Gene:	Emx1  Location: Chr6:85164913-85181445 bp, + strand  Genetic Position: Chr6, 37.21 cM
Alliance:	Emx1tm1Jlr page

Germline Transmission:	Earliest citation of germline transmission: J:35060
Parent Cell Line:	JM-1 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Insertion of a PGK-neomycin resistance cassette replaced exon 1 and part of intron 1 of the Emx1 gene. Northern analysis of E14.5 embryos did not detect Emx1 transcript in homozygous mutant mice. The authors predict that the mutant allele would produce a truncated protein that lacks the N-terminus. (J:35060)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	37 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Emx1 Mutation:	34 strains or lines available

Original:	J:35060 Qiu M, et al., Mutation of the Emx-1 homeobox gene disrupts the corpus callosum. Dev Biol. 1996 Aug 25;178(1):174-8
All:	7 reference(s)