Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Alox15tm1Fun
Name:	arachidonate 15-lipoxygenase; targeted mutation 1, Colin D Funk
MGI ID:	MGI:1857428
Synonyms:	12/15-LO-, 12/15-LO KO, 12Lox KO, L-12/15-LOX KO, L-12LO-
Gene:	Alox15  Location: Chr11:70234978-70242857 bp, - strand  Genetic Position: Chr11, 42.99 cM
Alliance:	Alox15tm1Fun page

Germline Transmission:	Earliest citation of germline transmission: J:44778
Parent Cell Line:	D3H (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Insertion of a neomycin resistance cassette into exon 3 disrupted the Alox15 gene. Northern blot analyses of resident peritoneal macrophages and of bone marrow-derived macrophages did not detect transcript in homozygous mutant mice. Western blot analysis of resident peritoneal macrophages did not detect ALOX15 in homozygous mutant mice. (J:44778)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	9 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Alox15 Mutation:	42 strains or lines available

Original:	J:44778 Sun D, et al., Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J Biol Chem. 1996 Sep 27;271(39):24055-62
All:	109 reference(s)