Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Dsg3tm1Stan Name: desmoglein 3; targeted mutation 1, John R Stanley MGI ID: MGI:1857388 Synonyms: Dsg3- Gene: Dsg3  Location: Chr18:20643331-20674367 bp, + strand  Genetic Position: Chr18, 11.39 cM Alliance: Dsg3tm1Stan page

Dsg3tm1Stan/Dsg3tm1Stan mice are runts and have skin erosions and eye lesions Show the 6 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:40804
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Replacement of part of the first exon, including the translation initiation site, with a neomycin cassette. Dsg3 RNA and protein were not detected in mice homozygous for this targeted mutation. (J:40804)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dsg3 Mutation:	73 strains or lines available

Original:	J:40804 Koch PJ, et al., Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol. 1997 Jun 2;137(5):1091-102
All:	27 reference(s)