Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Twist1tm1Bhr
Name:	twist basic helix-loop-helix transcription factor 1; targeted mutation 1, Richard R Behringer
MGI ID:	MGI:1857265
Synonyms:	twist-1-, twist1del
Gene:	Twist1  Location: Chr12:34007670-34009828 bp, + strand  Genetic Position: Chr12, 14.81 cM, cytoband B-C1
Alliance:	Twist1tm1Bhr page

Germline Transmission:	Earliest citation of germline transmission: J:24349
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion     A neomycin selection cassette replaced exon 1, which contains the entire coding region. (J:24349)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	266 assay results 3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Twist1 Mutation:	18 strains or lines available

Original:	J:24349 Chen ZF, et al., twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev. 1995 Mar 15;9(6):686-99
All:	47 reference(s)