Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Nppatm1Unc
Name:	natriuretic peptide type A; targeted mutation 1, University of North Carolina
MGI ID:	MGI:1857231
Synonyms:	ANP-, proANP-
Gene:	Nppa  Location: Chr4:148085179-148086531 bp, + strand  Genetic Position: Chr4, 78.66 cM
Alliance:	Nppatm1Unc page

Germline Transmission:	Earliest citation of germline transmission: J:76312
Parent Cell Line:	E14TG2a (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 11 bp of exon 2 was replaced with a neomycin resistance gene via homologous recombination. Radioimmunoassay of plasma and atria from homozygous mutant animals did not detect protein product. (J:76312)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nppa Mutation:	10 strains or lines available

Original:	J:76312 John SW, et al., Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science. 1995 Feb 3;267(5198):679-81
All:	32 reference(s)