Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ass1tm1Bay
Name:	argininosuccinate synthetase 1; targeted mutation 1, Baylor College of Medicine
MGI ID:	MGI:1857131
Synonyms:	Ass-
Gene:	Ass1  Location: Chr2:31360282-31410682 bp, + strand  Genetic Position: Chr2, 21.81 cM
Alliance:	Ass1tm1Bay page

Germline Transmission:	Earliest citation of germline transmission: J:18326
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: A neomycin resistance cassette was inserted into exon 4 of the gene. Activity assays in liver extracts from homozygous mice demostrated the absence of the functional protein. (J:18326)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ass1 Mutation:	56 strains or lines available

Original:	J:18326 Patejunas G, et al., Generation of a mouse model for citrullinemia by targeted disruption of the argininosuccinate synthetase gene. Somat Cell Mol Genet. 1994 Jan;20(1):55-60
All:	5 reference(s)