Fgfrl1tm1True
Targeted Allele Detail
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Symbol: |
Fgfrl1tm1True |
Name: |
fibroblast growth factor receptor-like 1; targeted mutation 1, Beat Trueb |
MGI ID: |
MGI:3771861 |
Synonyms: |
Fgfrl1- |
Gene: |
Fgfrl1 Location: Chr5:108842051-108854816 bp, + strand Genetic Position: Chr5, 53.24 cM, cytoband E3-F
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Alliance: |
Fgfrl1tm1True page
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Smaller and thinner diaphragms in Fgfrl1tm1True/Fgfrl1tm1True mice but not in Fgfrl1tm2.1True/Fgfrl1tm2.1True mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:130254
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Parent Cell Line: |
iTL1 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A DNA segement stretching from within the promoter to intron 1 was replaced with a neo cassette. The absence of transcript containing exon 1 and the presence of a transcript containing the neo cassette was confirmed by northern blot analysis.
(J:130254)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Fgfrl1 Mutation: |
28 strains or lines available
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Original: |
J:130254 Baertschi S, et al., Mice with a targeted disruption of the Fgfrl1 gene die at birth due to alterations in the diaphragm. FEBS J. 2007 Dec;274(23):6241-53 |
All: |
5 reference(s) |
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