Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Ptprbtm1Gdy Name: protein tyrosine phosphatase receptor type B; targeted mutation 1, George D Yancopoulos MGI ID: MGI:3763454 Synonyms: VE-PTP- Gene: Ptprb  Location: Chr10:116111428-116225440 bp, + strand  Genetic Position: Chr10, 64.68 cM, cytoband D2 Alliance: Ptprbtm1Gdy page

Angiogenic defects in Ptprbtm1Gdy/Ptprbtm1Gdy mouse embryos Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:125903
Parent Cell Line:	F1H4 (ES Cell)
Strain of Origin:	(129S6/SvEvTac x C57BL/6NTac)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: An 11.8-kb segment of the gene extending from 27 nucleotides in exon 2 through exon 3 was replaced with a beta-gal reporter gene and a loxP-flanked neomycin selection cassette. Quantitative RT-PCR on 9.5 embryos demonstrated no gene expression in homozygotes. Beta-gal expression was observed in the developing cardiovascular system. (J:125903)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprb Mutation:	99 strains or lines available

Original:	J:125903 Dominguez MG, et al., Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3243-8
All:	2 reference(s)