About   Help   FAQ
Gene Expression Data
Assay Details
Assay
Reference: J:97231 Koop EA, et al., Receptor protein tyrosine phosphatase mu expression as a marker for endothelial cell heterogeneity; analysis of RPTPmu gene expression using LacZ knock-in mice. Int J Dev Biol. 2003 Jun;47(5):345-54
Assay type: In situ reporter (knock in)
MGI Accession ID: MGI:3761810
Gene symbol: Ptprm
Gene name: protein tyrosine phosphatase receptor type M
Reporter: lacZ
Direct Detection
Assay notes: Embryos were fixed in 1% paraformaldehyde and 0.2% glutaraldehyde and postfixed in 4% paraformaldehyde.
Results
Specimen Not shown: embryonic day 6.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS9: embryo Absent

Specimen 2A: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: Rathke's pouch Present 2A
TS15: diencephalon lamina terminalis Present 2A
TS15: diencephalon roof plate Present 2A
TS15: heart Present 2A
TS15: telencephalon roof plate Present 2A
TS15: blood vessel Present Regionally restricted 2A Expression is in somitic vessels.

Specimen 2B: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: Rathke's pouch Present Spotted 2B

Specimen 2C: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: 1st branchial pouch Present 2C
TS15: 2nd arch artery Present 2C
TS15: 2nd branchial pouch Present 2C

Specimen 2D: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: common atrial chamber endocardial lining Present 2D
TS15: dorsal aorta Present 2D
TS15: primitive ventricle endocardial lining Present 2D
TS15: heart atrium Present Regionally restricted 2D Expression is in the endothelium.

Specimen Not shown: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: olfactory placode Present Regionally restricted Expression is in the olfactory placode, in the dorsal part of the oropharynx.

Specimen 3A: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: choroid invagination Present Regionally restricted 3A Expression is in the choroidal fissure.
TS20: epithalamus Absent 3A
TS20: thalamus Absent 3A

Specimen 3B: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: diencephalon mantle layer Present Regionally restricted 3B Expression is in the mantle layers of the ventricle.
TS20: hindbrain mantle layer Present Regionally restricted 3B Expression is in the mantle layers of the ventricle.
TS20: diencephalon lamina terminalis Present 3B
TS20: diencephalon floor plate Present Regionally restricted 3B
TS20: diencephalon roof plate Present Regionally restricted 3B

Specimen 3C: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: choroid plexus Present Regionally restricted 3C Expression is in the vessels of the choroid plexus.

Specimen 3D: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: olfactory epithelium Present 3D

Specimen 3E: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: atrium endocardial lining Present Regionally restricted 3E Expression is in the endothelium.
TS20: dorsal aorta Present Regionally restricted 3E Expression is in the endothelium.
TS20: ventricle endocardial lining Present Regionally restricted 3E Expression is in the endothelium.

Specimen 3F: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: pulmonary artery Present 3F
TS20: blood vessel Present Regionally restricted 3F Expression is in small vessels in the lung.
TS20: lobar bronchus Absent 3F

Specimen 3G: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: hyaloid cavity Present 3G
TS20: optic stalk Present Regionally restricted 3G Expression is in vessels.

Specimen 3H: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: liver Absent 3H
TS20: venous system Weak Regionally restricted 3H Weak expression in the hepatic vein.

Specimen Not shown: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: cardiovascular system Present Regionally restricted The vasculature showed expression in almost all capillaries and arteries throughout the embryo.

Specimen 4A: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: heart Present 4A

Specimen 4B: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: arterial system Present Regionally restricted 4B Expression is in the endothelium of the coronary arteries.
TS28: heart Present Regionally restricted 4B Expression is in myocytes.

Specimen 4C: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: lung Present 4C

Specimen 4D: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: pulmonary artery Present Regionally restricted 4D Expression is in the endothelium.
TS28: bronchus Absent 4D

Specimen 4E: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: lung alveolus Present Regionally restricted 4E Expression is in type II pneumonocytes of the lung alveoli.

Specimen 4F: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present 4F

Specimen 4G: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: meninges Present Regionally restricted 4G Expression is in the leptomeninges.

Specimen 4H: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: cerebellum Purkinje cell layer Present 4H

Specimen 4I: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: cerebral cortex Present 4I

Specimen 5A: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: blood vessel Present Regionally restricted 5A Expression is in the capillaries in the brain.

Specimen 5B: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: body wall Present Regionally restricted 5B Expression is in capillaries.
TS20: heart ventricle Present Regionally restricted 5B Expression is in capillaries.

Specimen 5C: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: blood vessel Present Regionally restricted 5C Expression is in capillaries of the stomach.

Specimen 5D: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: capillary Present Regionally restricted 5D Expression is in capillaries of the brain.

Specimen 5E: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: capillary Present Regionally restricted 5E Expression is in capillaries of the heart.

Specimen 5F: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: capillary Present Regionally restricted 5F Expression is in capillaries of skeletal muscle.
TS28: skeletal muscle Absent 5F

Specimen 5G: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: artery Present Regionally restricted 5G Expression is in the small arteries of the liver.

Specimen 5H: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: artery Present Regionally restricted 5H Expression is in the small arteries of the spleen.

Specimen Not shown: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: capillary Present Regionally restricted Expression is in the capillaries of the gut, the gonads, the kidney, and the skeletal muscles.

Specimen 6A: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: dorsal aorta Strong Regionally restricted 6A Expression is in endothelial cells.
TS20: cardinal vein Trace Regionally restricted 6A Expression is in endothelial cells.

Specimen 6B: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: arterial system Strong 6B
TS20: venous system Trace 6B The veins showed low or no expression.

Specimen 6C: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: arterial system Strong Regionally restricted 6C Expression is in the vitelline vessel.
TS20: venous system Trace Regionally restricted 6C Low or absent in the vitelline vessel.

Specimen 6D: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: arterial system Strong 6D Shown is the liver.
TS20: venous system Trace 6D Shown is the liver. Expression in veins is negative or only weakly positive.

Specimen 6E: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: arterial system Strong 6E Shown is the umbilical cord.
TS20: venous system Trace 6E Shown is the umbilical cord. Expression in veins is negative or only weakly positive.

Specimen 6F: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: arterial system Strong 6F Shown is the tail.
TS20: venous system Trace 6F Shown is the tail. Expression in veins is negative or only weakly positive.

Specimen 7A,B: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: artery Present 7A , 7B Shown is the bladder.
TS28: vein Absent 7A , 7B Shown is the bladder.

Specimen 7C,D: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: artery Present 7D , 7C Shown are the seminal vesicles.
TS28: vein Absent 7D , 7C Shown are the seminal vesicles.

Specimen 7E,F: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: artery Present 7F , 7E Shown is the uterus.
TS28: vein Absent 7E , 7F Shown is the uterus.

Specimen 8A,D: embryonic day 9.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS15: dorsal aorta Present Regionally restricted 8A , 8D Expression is in the endothelium.
TS15: arterial system Present Regionally restricted 8A , 8D Expression is in the endothelium of the ductus arteriosus.
TS15: endocardial lining Present 8D , 8A

Specimen 8B,E: embryonic day 12.5; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS20: dorsal aorta Present Regionally restricted 8B , 8E Expression is in the endothelium.
TS20: arterial system Present Regionally restricted 8E , 8B Expression is in the endothelium of the ductus arteriosus.
TS20: endocardial lining Present 8B , 8E

Specimen 8C: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: aorta Absent 8C Absent in the aorta itself, but is present in the side branches.

Specimen 8F: postnatal adult; Ptprmtm1Mfbg/Ptprm+ (more )
Structure Level Pattern Image Note
TS28: heart ventricle Absent 8F


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/28/2024
MGI 6.13
The Jackson Laboratory