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Gene Expression Data
Assay Details
Assay
Reference: J:54206 Jung HS, et al., Shh, Bmp-2, Bmp-4 and Fgf-8 are associated with initiation and patterning of mouse tongue papillae. Mech Dev. 1999 Mar;81(1-2):179-82
Assay type: RNA in situ
MGI Accession ID: MGI:2671103
Gene symbol: Bmp4
Gene name: bone morphogenetic protein 4
Probe: Bmp4 probe16
Probe preparation: Antisense labelled with digoxigenin RNA
Results
Specimen 1C: embryonic day 11.0 (more )
Structure Level Pattern Image Note
TS18: lateral lingual swelling Weak Regionally restricted 1C Expression is absent in the median sulcus.

Specimen 1G: embryonic day 11.5 (more )
Structure Level Pattern Image Note
TS19: lateral lingual swelling epithelium Present Graded 1G Highest expression is at the periphery with an apparent down-regulation in the central area of the tongue.
TS19: median lingual swelling epithelium Present Graded 1G Highest expression is at the periphery with an apparent down-regulation in the central area of the tongue.
TS19: dental placode Present 1G Expression is in the developing incisor and molar tooth buds.

Specimen 1K: embryonic day 12.5 (more )
Structure Level Pattern Image Note
TS20: lateral lingual swelling epithelium Present Spotted 1K Expression in spots in the posterior part of the tongue and weakly in rows of spots running parallel to the median sulcus in the anterior part.
TS20: median lingual swelling epithelium Present Spotted 1K Expression in spots in the posterior part of the tongue and weakly in rows of spots running parallel to the median sulcus in the anterior part.

Specimen 1O: embryonic day 13.5 (more )
Structure Level Pattern Image Note
TS21: tongue epithelium Present Spotted 1O The expression is in punctate patches at regular intervals often symmetrically located in rows at both sides of the median sulcus.

Specimen 1R: embryonic day 14.5 (more )
Structure Level Pattern Image Note
TS22: tongue epithelium Weak Spotted 1R There are fewer spots than at E13.5

Specimen 1U: embryonic day 15.5 (more )
Structure Level Pattern Image Note
TS23: tongue epithelium Absent 1U Authors report that expression is completely downregulated.

Specimen 2C: embryonic day 11.0 (more )
Note: Embryos were embedded in a gelatin/albumin mixture and 80-100 micron vibratome sections were cut.
Structure Level Pattern Image Note
TS18: lateral lingual swelling epithelium Strong Regionally restricted 2C Expression is in the dorsal epithelium.
TS18: median lingual swelling epithelium Strong Regionally restricted 2C Expression is in the dorsal epithelium.
TS18: lateral lingual swelling mesenchyme Weak 2C
TS18: median lingual swelling mesenchyme Weak 2C

Specimen 2G: embryonic day 12.5 (more )
Note: Embryos were embedded in a gelatin/albumin mixture and 80-100 micron vibratome sections were cut.
Structure Level Pattern Image Note
TS20: lateral lingual swelling epithelium Present Spotted 2G
TS20: median lingual swelling epithelium Present Spotted 2G

Specimen 2K: embryonic day 13.5 (more )
Note: Embryos were embedded in a gelatin/albumin mixture and 80-100 micron vibratome sections were cut.
Structure Level Pattern Image Note
TS21: tongue epithelium Present Spotted 2K Expression is in the dorsal epithelium.

Specimen 2L: embryonic day 13.5 (more )
Note: Embryos were embedded in a gelatin/albumin mixture and 80-100 micron vibratome sections were cut.
Structure Level Pattern Image Note
TS21: tongue epithelium Present Single cells 2L Expression is in a spot of 6-8 cells.

Specimen 2O: embryonic day 15.5 (more )
Note: Embryos were embedded in a gelatin/albumin mixture and 80-100 micron vibratome sections were cut.
Structure Level Pattern Image Note
TS23: tongue epithelium Absent 2O Expression is completely downregulated in the dorsal epithelium.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/18/2025
MGI 6.24
The Jackson Laboratory