Twsg1tm1Nosa
Targeted Allele Detail
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Symbol: |
Twsg1tm1Nosa |
Name: |
twisted gastrulation BMP signaling modulator 1; targeted mutation 1, Tetsuya Nosaka |
MGI ID: |
MGI:2655736 |
Synonyms: |
Twsg1- |
Gene: |
Twsg1 Location: Chr17:66230060-66258198 bp, - strand Genetic Position: Chr17, 35.26 cM
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Alliance: |
Twsg1tm1Nosa page
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Germline Transmission: |
Earliest citation of germline transmission:
J:82738
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Parent Cell Line: |
E14.1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: Exon 1 was disrupted by homologous recombination of a targeting construct containing a neomycin selection cassette. The targeted exon encoded the first 40 amino acids, including the signal sequence. Northern blot analysis of homozygous mutant mice showed low levels of truncated transcript. Any protein translated from this message would lack a signal sequence and therefore would be expected to be non-functional.
(J:82738)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Twsg1 Mutation: |
20 strains or lines available
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Original: |
J:82738 Nosaka T, et al., Mammalian twisted gastrulation is essential for skeleto-lymphogenesis. Mol Cell Biol. 2003 Apr;23(8):2969-80 |
All: |
3 reference(s) |
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