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Shh cDNA2 Probe Detail
Nucleotide
Probe/Clone
  • Name
    Shh cDNA2
  • Sequence Type
    cDNA
  • ID
    MGI:23359
  • Vector Type
    Plasmid
  • Note
    Two clones were used for making Shh riboprobes in Echlard et al. (J:16386), either a .64kb one (MGI:1327804) or a 2.8 kb one (MGI:1929246). Later authors did not specify which of the two probes they used.
  • Synonyms
    Hh-16.1
Source
  • Species
    mouse, laboratory
  • Age
    embryonic day 8.5
Genes
Shh sonic hedgehog
Expression
  • Assay Results
    713
References
J:16386 Echelard Y, et al., Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell. 1993 Dec 31;75(7):1417-30
J:23131 Conlon FL, et al., Effects of the TWis mutation on notochord formation and mesodermal patterning. Mech Dev. 1995 Feb;49(3):201-9
J:23134 Faust C, et al., The eed mutation disrupts anterior mesoderm production in mice. Development. 1995 Feb;121(2):273-85
J:25248 Conlon RA, et al., Notch1 is required for the coordinate segmentation of somites. Development. 1995 May;121(5):1533-45
J:27786 Chan DC, et al., Polydactylous limbs in Strong's Luxoid mice result from ectopic polarizing activity. Development. 1995 Jul;121(7):1971-8
J:28010 Marti E, et al., Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo. Development. 1995 Aug;121(8):2537-47
J:31608 Zwart R, et al., The restricted expression pattern of the POU factor Oct-6 during early development of the mouse nervous system. Mech Dev. 1996 Feb;54(2):185-94
J:34768 Tremblay P, et al., Inhibition of floor plate differentiation by Pax3: evidence from ectopic expression in transgenic mice. Development. 1996 Aug;122(8):2555-67
J:35809 Epstein DJ, et al., Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development. 1996 Sep;122(9):2885-94
J:36834 Torres M, et al., Pax2 contributes to inner ear patterning and optic nerve trajectory. Development. 1996 Nov;122(11):3381-91
J:38380 Kuhlman J, et al., Limb deformity proteins: role in mesodermal induction of the apical ectodermal ridge. Development. 1997 Jan;124(1):133-9
J:38381 Mo R, et al., Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development. 1997 Jan;124(1):113-23
J:39203 Varlet I, et al., nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation. Development. 1997 Mar;124(5):1033-44
J:39344 Yoshikawa Y, et al., Evidence that absence of Wnt-3a signaling promotes neuralization instead of paraxial mesoderm development in the mouse. Dev Biol. 1997 Mar 15;183(2):234-42
J:39658 Buscher D, et al., Evidence for genetic control of Sonic hedgehog by Gli3 in mouse limb development. Mech Dev. 1997 Mar;62(2):175-82
J:39659 Platt KA, et al., Expression of the mouse Gli and Ptc genes is adjacent to embryonic sources of hedgehog signals suggesting a conservation of pathways between flies and mice. Mech Dev. 1997 Mar;62(2):121-35
J:41684 Lee J, et al., Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development. 1997 Jul;124(13):2537-52
J:41809 Filosa S, et al., goosecoid and HNF-3 beta genetically interact to regulate neural tube patterning during mouse embryogenesis. Development. 1997 JUL;124(14):2843-2854
J:43579 Kitamura K, et al., Expression patterns of Brx1 (Rieg gene), Sonic hedgehog, Nkx2.2, Dlx1 and Arx during zona limitans intrathalamica and embryonic ventral lateral geniculate nuclear formation. Mech Dev. 1997 Sep;67(1):83-96
J:45301 Cygan JA, et al., Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec;124(24):5021-32
J:45211 Buscher D, et al., Expression profile of Gli family members and Shh in normal and mutant mouse limb development. Dev Dyn. 1998 Jan;211(1):88-96
J:45907 Motoyama J, et al., Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog [letter]. Nat Genet. 1998 Feb;18(2):104-6
J:47700 Greene ND, et al., Abnormalities of floor plate, notochord and somite differentiation in the loop-tail (Lp) mouse: a model of severe neural tube defects. Mech Dev. 1998 Apr;73(1):59-72
J:49164 Ding Q, et al., Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development. 1998 Jul;125(14):2533-43
J:49251 Matise MP, et al., Gli2 is required for induction of floor plate and adjacent cells, but not most ventral neurons in the mouse central nervous system. Development. 1998 Aug;125(15):2759-70
J:49653 Yang Y, et al., Evidence that preaxial polydactyly in the Doublefoot mutant is due to ectopic Indian Hedgehog signaling. Development. 1998 Aug;125(16):3123-32
J:49657 Dufort D, et al., The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development. 1998 Aug;125(16):3015-25
J:49808 Crackower MA, et al., Defect in the maintenance of the apical ectodermal ridge in the Dactylaplasia mouse. Dev Biol. 1998 Sep 1;201(1):78-89
J:50462 Dassule HR, et al., Analysis of epithelial-mesenchymal interactions in the initial morphogenesis of the mammalian tooth. Dev Biol. 1998 Oct 15;202(2):215-27
J:50582 Roebroek AJ, et al., Failure of ventral closure and axial rotation in embryos lacking the proprotein convertase Furin. Development. 1998 Dec;125(24):4863-76
J:51701 Motoyama J, et al., Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis. Mech Dev. 1998 Nov;78(1-2):81-4
J:49322 Zuniga A, et al., Gli3 (Xt) and formin (ld) participate in the positioning of the polarising region and control of posterior limb-bud identity. Development. 1999 Jan;126(1):13-21
J:51127 Epstein DJ, et al., Regionalization of Sonic hedgehog transcription along the anteroposterior axis of the mouse central nervous system is regulated by Hnf3-dependent and -independent mechanisms. Development. 1999 Jan;126(2):281-92
J:52212 Lu MF, et al., Paired-related homeobox genes cooperate in handplate and hindlimb zeugopod morphogenesis. Dev Biol. 1999 Jan 1;205(1):145-57
J:53294 Solloway MJ, et al., Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup. Development. 1999 Apr;126(8):1753-68
J:53903 Theil T, et al., Gli3 is required for Emx gene expression during dorsal telencephalon development. Development. 1999 Aug;126(16):3561-71
J:56195 Milenkovic L, et al., Mouse patched1 controls body size determination and limb patterning. Development. 1999 Oct;126(20):4431-40
J:56424 Goodrich LV, et al., Overexpression of ptc1 inhibits induction of Shh target genes and prevents normal patterning in the neural tube. Dev Biol. 1999 Jul 15;211(2):323-34
J:58413 Wasiak S, et al., Retinoic acid affects left-right patterning. Dev Biol. 1999 Nov 15;215(2):332-42
J:58627 Grotewold L, et al., Expression pattern of Dkk-1 during mouse limb development. Mech Dev. 1999 Dec;89(1-2):151-3
J:56581 Daubas P, et al., Myf5 is a novel early axonal marker in the mouse brain and is subjected to post-transcriptional regulation in neurons. Development. 2000 Jan;127(2):319-31
J:60986 Park HL, et al., Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development. 2000 Apr;127(8):1593-605
J:62028 Charite J, et al., The bHLH transcription factor dHAND controls Sonic hedgehog expression and establishment of the zone of polarizing activity during limb development. Development. 2000 Jun;127(11):2461-70
J:63681 Martinez-Barbera JP, et al., The homeobox gene Hesx1 is required in the anterior neural ectoderm for normal forebrain formation. Dev Biol. 2000 Jul 15;223(2):422-30
J:64329 Welsh IC, et al., Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse. Dev Biol. 2000 Sep 1;225(1):151-68
J:67154 Nery S, et al., Sonic hedgehog contributes to oligodendrocyte specification in the mammalian forebrain. Development. 2001 Feb;128(4):527-40
J:68215 Xue Y, et al., Mesodermal patterning defect in mice lacking the Ste20 NCK interacting kinase (NIK). Development. 2001 May;128(9):1559-72
J:69854 Liu C, et al., Regulation of left-right asymmetry by thresholds of Pitx2c activity. Development. 2001 Jun;128(11):2039-48
J:72380 Makino S, et al., A Spontaneous Mouse Mutation, mesenchymal dysplasia (mes), Is Caused by a Deletion of the Most C-Terminal Cytoplasmic Domain of patched (ptc). Dev Biol. 2001 Nov 1;239(1):95-106
J:74631 Tian E, et al., Otx2 is required to respond to signals from anterior neural ridge for forebrain specification. Dev Biol. 2002 Feb 15;242(2):204-23
J:75698 Grunder A, et al., Nuclear factor I-B (Nfib) deficient mice have severe lung hypoplasia. Mech Dev. 2002 Mar;112(1-2):69-77
J:75942 Ybot-Gonzalez P, et al., Sonic hedgehog and the molecular regulation of mouse neural tube closure. Development. 2002 May;129(10):2507-17
J:75946 Kanai-Azuma M, et al., Depletion of definitive gut endoderm in Sox17-null mutant mice. Development. 2002 May;129(10):2367-79
J:77125 Norris DP, et al., The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. Development. 2002 Jul;129(14):3455-68
J:80177 Aoto K, et al., Mouse GLI3 Regulates Fgf8 Expression and Apoptosis in the Developing Neural Tube, Face, and Limb Bud. Dev Biol. 2002 Nov 15;251(2):320-32
J:82193 Murdoch JN, et al., Genomic organization and embryonic expression of Igsf8, an immunoglobulin superfamily member implicated in development of the nervous system and organ epithelia. Mol Cell Neurosci. 2003 Jan;22(1):62-74
J:82633 Adamska M, et al., Doubleridge, a mouse mutant with defective compaction of the apical ectodermal ridge and normal dorsal-ventral patterning of the limb. Dev Biol. 2003 Mar 15;255(2):350-62
J:83258 Rallis C, et al., Tbx5 is required for forelimb bud formation and continued outgrowth. Development. 2003 Jun;130(12):2741-51
J:84056 Motoyama J, et al., Differential requirement for Gli2 and Gli3 in ventral neural cell fate specification. Dev Biol. 2003 Jul 1;259(1):150-61
J:86839 Liguori GL, et al., Anterior neural plate regionalization in cripto null mutant mouse embryos in the absence of node and primitive streak. Dev Biol. 2003 Dec 15;264(2):537-49
J:93140 Lu CC, et al., Multiple roles for Nodal in the epiblast of the mouse embryo in the establishment of anterior-posterior patterning. Dev Biol. 2004 Sep 1;273(1):149-59
J:95686 Keegan CE, et al., Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused by a splicing mutation in a novel telomeric regulator. Hum Mol Genet. 2005 Jan 1;14(1):113-23
J:97076 Furushima K, et al., Characterization of Opr deficiency in mouse brain: Subtle defects in dorsomedial telencephalon and medioventral forebrain. Dev Dyn. 2005 Apr;232(4):1056-61
J:99098 Hester M, et al., Smad1 and Smad8 function similarly in mammalian central nervous system development. Mol Cell Biol. 2005 Jun;25(11):4683-92
J:101265 Kuijper S, et al., Function and regulation of Alx4 in limb development: complex genetic interactions with Gli3 and Shh. Dev Biol. 2005 Sep 15;285(2):533-44
J:119913 Haraguchi R, et al., Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling. Development. 2007 Feb;134(3):525-33
J:121311 Liu Z, et al., Gcm2 is required for the differentiation and survival of parathyroid precursor cells in the parathyroid/thymus primordia. Dev Biol. 2007 May 1;305(1):333-46
J:127128 Rock JR, et al., Identification of genes expressed in the mouse limb using a novel ZPA microarray approach. Gene Expr Patterns. 2007 Dec;8(1):19-26
J:136719 Maretto S, et al., Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3. Dev Biol. 2008 Jun 1;318(1):184-93
J:136720 Friedrichs M, et al., Lamination of the cerebral cortex is disturbed in Gli3 mutant mice. Dev Biol. 2008 Jun 1;318(1):203-14
J:142648 Castranio T, et al., Bmp2 is required for cephalic neural tube closure in the mouse. Dev Dyn. 2008 Dec 18;238(1):110-122
J:144057 Hockman D, et al., A second wave of Sonic hedgehog expression during the development of the bat limb. Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16982-7
J:145173 Pantalacci S, et al., Patterning of palatal rugae through sequential addition reveals an anterior/posterior boundary in palatal development. BMC Dev Biol. 2008;8:116
J:145734 Daubas P, et al., The regulatory mechanisms that underlie inappropriate transcription of the myogenic determination gene Myf5 in the central nervous system. Dev Biol. 2009 Mar 1;327(1):71-82
J:154376 Stottmann RW, et al., Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain. Dev Biol. 2009 Nov 1;335(1):166-78
J:163739 Leung AW, et al., Loss of procollagen IIA from the anterior mesendoderm disrupts the development of mouse embryonic forebrain. Dev Dyn. 2010 Sep;239(9):2319-29
J:166847 Tonissoo T, et al., Nucleotide exchange factor RIC-8 is indispensable in mammalian early development. Dev Dyn. 2010 Dec;239(12):3404-15
J:181884 Quinn ME, et al., Preaxial polydactyly caused by Gli3 haploinsufficiency is rescued by Zic3 loss of function in mice. Hum Mol Genet. 2012 Apr 15;21(8):1888-96
J:217498 Anderson E, et al., Mapping the Shh long-range regulatory domain. Development. 2014 Oct;141(20):3934-43
J:226614 Costello I, et al., Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development. Genes Dev. 2015 Oct 15;29(20):2108-22
J:229383 Serth K, et al., Generation of an 870 kb deletion encompassing the Skt/Etl4 locus by combination of inter- and intra-chromosomal recombination. BMC Genet. 2015;16:143
J:309436 Parish EV, et al., Expression of Barhl2 and its relationship with Pax6 expression in the forebrain of the mouse embryo. BMC Neurosci. 2016 Nov 25;17(1):76
J:320708 Benabdallah NS, et al., SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells. Open Biol. 2016 Nov;6(11)
J:243416 Ahn Y, et al., Multiple modes of Lrp4 function in modulation of Wnt/beta-catenin signaling during tooth development. Development. 2017 Aug 01;144(15):2824-2836
J:245730 Bardot P, et al., The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo. Development. 2017 Oct 15;144(20):3808-3818
J:278736 Cheong A, et al., A null allele of Dnaaf2 displays embryonic lethality and mimics human ciliary dyskinesia. Hum Mol Genet. 2019 Aug 15;28(16):2775-2784
J:290235 Archambault D, et al., Protein phosphatase 1 regulatory subunit 35 is required for ciliogenesis, notochord morphogenesis, and cell-cycle progression during murine development. Dev Biol. 2020 Jul 3;465(1):1-10
J:306168 Haraguchi R, et al., New Insights into Development of Female Reproductive Tract-Hedgehog-Signal Response in Wolffian Tissues Directly Contributes to Uterus Development. Int J Mol Sci. 2021 Jan 26;22(3)
J:339600 Hermosilla Aguayo V, et al., ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling. Dev Biol. 2023 Aug 10;503:25-42

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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory