Pla2g4atm1Jvb
Targeted Allele Detail
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Symbol: |
Pla2g4atm1Jvb |
Name: |
phospholipase A2, group IVA (cytosolic, calcium-dependent); targeted mutation 1, Joseph V Bonventre |
MGI ID: |
MGI:2181427 |
Synonyms: |
cPLA2-, cPLA2alpha-, cPLA2-KO, gIVaPLA2null, Pla2g4a- |
Gene: |
Pla2g4a Location: Chr1:149705369-149837041 bp, - strand Genetic Position: Chr1, 63.51 cM
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Alliance: |
Pla2g4atm1Jvb page
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Germline Transmission: |
Earliest citation of germline transmission:
J:39681
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacement of sequences encoding amino acids 187-232 with a PGK-neo-polyA cassette via homologous recombination. Protein product was absent in various organ samples from homozygous mutant animals as determined by Western blot analysis.
(J:39681)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Pla2g4a Mutation: |
61 strains or lines available
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Original: |
J:39681 Bonventre JV, et al., Reduced fertility and postischaemic brain injury in mice deficient in cytosolic phospholipase A2. Nature. 1997 Dec 11;390(6660):622-5 |
All: |
53 reference(s) |
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