About   Help   FAQ
pmcRet7 Probe Detail
Nucleotide
Probe/Clone
  • Name
    pmcRet7
  • Sequence Type
    cDNA
  • ID
    MGI:17850
  • Region Covered
    3' portion of coding region (a small part of the extracellular domain, the transmembrane and intracellular domains) and 3' untranslated region.
  • Vector Type
    Plasmid
  • Insert Site
    NotI
  • Note
    A 3.3kb transcript was generated after SacII digestion (J:52599).
Source
  • Species
    mouse, laboratory
  • Tissue
    neuroblast
  • Cell Line
    neuroblastoma cell line Nb/2a
Genes
Ret ret proto-oncogene
Expression
  • Assay Results
    181
References
J:16246 Pachnis V, et al., Expression of the c-ret proto-oncogene during mouse embryogenesis. Development. 1993 Dec;119(4):1005-17
J:30246 Sommer L, et al., The cellular function of MASH1 in autonomic neurogenesis. Neuron. 1995 Dec;15(6):1245-58
J:35809 Epstein DJ, et al., Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway. Development. 1996 Sep;122(9):2885-94
J:45763 Arce V, et al., Synergistic effects of schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1). J Neurosci. 1998 Feb 15;18(4):1440-8
J:46409 Hirsch MR, et al., Control of noradrenergic differentiation and Phox2a expression by MASH1 in the central and peripheral nervous system. Development. 1998 Feb;125(4):599-608
J:46667 Fode C, et al., The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron. 1998 Mar;20(3):483-94
J:50697 Labosky PA, et al., The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development. Mech Dev. 1998 Aug;76(1-2):185-90
J:49702 Natarajan D, et al., Multipotential progenitors of the mammalian enteric nervous system capable of colonising aganglionic bowel in organ culture. Development. 1999 Jan;126(1):157-68
J:52599 Mendelsohn C, et al., Stromal cells mediate retinoid-dependent functions essential for renal development. Development. 1999 Mar;126(6):1139-48
J:63174 Garces A, et al., GFRalpha 1 is required for development of distinct subpopulations of motoneuron. J Neurosci. 2000 Jul 1;20(13):4992-5000
J:65601 Garel S, et al., Control of the migratory pathway of facial branchiomotor neurones. Development. 2000 Dec;127(24):5297-307
J:79480 Natarajan D, et al., Requirement of signalling by receptor tyrosine kinase RET for the directed migration of enteric nervous system progenitor cells during mammalian embryogenesis. Development. 2002 Nov;129(22):5151-60
J:81970 McCallion AS, et al., Phenotype variation in two-locus mouse models of Hirschsprung disease: tissue-specific interaction between Ret and Ednrb. Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1826-31
J:82111 Allmendinger A, et al., Development of adrenal chromaffin cells is largely normal in mice lacking the receptor tyrosine kinase c-Ret. Mech Dev. 2003 Mar;120(3):299-304
J:82126 Schnabel CA, et al., Pbx1 regulates nephrogenesis and ureteric branching in the developing kidney. Dev Biol. 2003 Feb 15;254(2):262-76
J:108109 Oxburgh L, et al., TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population. Development. 2004 Sep;131(18):4593-605
J:109593 Heanue TA, et al., Expression profiling the developing mammalian enteric nervous system identifies marker and candidate Hirschsprung disease genes. Proc Natl Acad Sci U S A. 2006 May 2;103(18):6919-24
J:137167 Tennese AA, et al., Loss of the Prader-Willi syndrome protein necdin causes defective migration, axonal outgrowth, and survival of embryonic sympathetic neurons. Dev Dyn. 2008 Jul;237(7):1935-43
J:139205 Heanue TA, et al., Ret isoform function and marker gene expression in the enteric nervous system is conserved across diverse vertebrate species. Mech Dev. 2008 Aug;125(8):687-99
J:171426 Chia I, et al., Nephric duct insertion is a crucial step in urinary tract maturation that is regulated by a Gata3-Raldh2-Ret molecular network in mice. Development. 2011 May;138(10):2089-97

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
05/07/2024
MGI 6.23
The Jackson Laboratory