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Gene Expression Data
Assay Details
Assay
Reference: J:55705 Nardelli J, et al., Expression and genetic interaction of transcription factors GATA-2 and GATA-3 during development of the mouse central nervous system. Dev Biol. 1999 Jun 15;210(2):305-21
Assay type: Immunohistochemistry
MGI Accession ID: MGI:1342736
Gene symbol: Nefm
Gene name: neurofilament, medium polypeptide
Results
Specimen 5.A: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: acoustic ganglion Present 5A
TS17: facial ganglion Present 5A
TS17: trigeminal ganglion Present 5A
TS17: cranial ganglion Present 5A Expression is detected in the common oculomotor (III) and trochlear (IV) nerves.
TS17: midbrain Present 5A
TS17: hindbrain Present 5A Expression is detected in the rostral hindbrain.

Specimen 5.B: embryonic day 10.5; Gata2tm1Sho/Gata2tm1Sho (more )
Structure Level Pattern Image Note
TS17: cranial ganglion Weak 5B Expression in the common oculomotor (III) and trochlear (IV) nerves is barely evidenced.
TS17: acoustic ganglion Present 5B These nerve complexes are clearly less developed in the mutant.
TS17: facial ganglion Present 5B These nerve complexes are clearly less developed in the mutant.
TS17: trigeminal ganglion Present 5B These nerve complexes are clearly less developed in the mutant.

Specimen 5.C: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: acoustic ganglion Present 5C
TS17: facial ganglion Present 5C
TS17: trigeminal ganglion Present 5C
TS17: cranial ganglion Present 5C Expression is detected in the common oculomotor (III) and trochlear (IV) nerves.
TS17: midbrain Present 5C
TS17: hindbrain Present 5C Expression is detected in the rostral hindbrain.

Specimen 5.D: embryonic day 10.5; Gata2tm1Sho/Gata2tm1Sho (more )
Structure Level Pattern Image Note
TS17: cranial ganglion Weak 5D Expression in the common oculomotor (III) and trochlear (IV) nerves is barely evidenced.
TS17: acoustic ganglion Present 5D These nerve complexes are clearly less developed in the mutant.
TS17: facial ganglion Present 5D These nerve complexes are clearly less developed in the mutant.
TS17: trigeminal ganglion Present 5D These nerve complexes are clearly less developed in the mutant.

Specimen 5.E: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: acoustic ganglion Present 5E Expression is detected in the common oculomotor (III) and trochlear (IV) nerves.
TS17: facial ganglion Present 5E Expression is detected in the common oculomotor (III) and trochlear (IV) nerves.
TS17: trigeminal ganglion Present 5E Expression is detected in the common oculomotor (III) and trochlear (IV) nerves.
TS17: cranial ganglion Present 5E
TS17: midbrain Present 5E
TS17: hindbrain Present 5E Expression is detected in the rostral hindbrain.

Specimen 5.F: embryonic day 10.5; Gata2tm1Sho/Gata2tm1Sho (more )
Structure Level Pattern Image Note
TS17: cranial ganglion Weak 5F Expression in the common oculomotor (III) and trochlear (IV) nerves is barely evidenced.
TS17: acoustic ganglion Present 5F These nerve complexes are clearly less developed in the mutant.
TS17: facial ganglion Present 5F These nerve complexes are clearly less developed in the mutant.
TS17: trigeminal ganglion Present 5F These nerve complexes are clearly less developed in the mutant.

Specimen 5.G: embryonic day 10.5 (more )
Structure Level Pattern Image Note
TS17: hindbrain Present 5G

Specimen 5.H: embryonic day 10.5; Gata2tm1Sho/Gata2tm1Sho (more )
Structure Level Pattern Image Note
TS17: hindbrain Present 5H Neurogenesis is impaired in the mutant in ventral r4. Almost no contralateral migration across the floor plate and a barely apparent exit point of trigeminal and facial/vestibuloacoustic nerves are seen.


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/28/2024
MGI 6.13
The Jackson Laboratory