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Lefty probe Probe Detail
Nucleotide
Probe/Clone
  • Name
    Lefty probe
  • Sequence Type
    cDNA
  • ID
    MGI:1289467
  • Region Covered
    includes a 3' portion of the coding region
  • Parent Clone
  • Vector Type
    Plasmid
  • Insert Site
    Aat1
  • Insert Size
    0.5 kb
Source
  • Species
    mouse, laboratory
  • Tissue
    embryo
  • Cell Line
    embryonal carcinoma cell line P19
Genes
Lefty1 left right determination factor 1
Lefty2 left-right determination factor 2
Expression
  • Assay Results
    113
References
J:32932 Meno C, et al., Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos. Nature. 1996 May 9;381(6578):151-5
J:49657 Dufort D, et al., The transcription factor HNF3beta is required in visceral endoderm for normal primitive streak morphogenesis. Development. 1998 Aug;125(16):3015-25
J:64329 Welsh IC, et al., Loss of late primitive streak mesoderm and interruption of left-right morphogenesis in the Ednrb(s-1Acrg) mutant mouse. Dev Biol. 2000 Sep 1;225(1):151-68
J:77125 Norris DP, et al., The Foxh1-dependent autoregulatory enhancer controls the level of Nodal signals in the mouse embryo. Development. 2002 Jul;129(14):3455-68
J:116645 Cota CD, et al., Mice with mutations in Mahogunin ring finger-1 (Mgrn1) exhibit abnormal patterning of the left-right axis. Dev Dyn. 2006 Dec;235(12):3438-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory