Hoxa MGI Mouse Complex/Cluster/Region Detail - MGI:96169

Hoxa Complex/Cluster/Region Detail

Symbol

Hoxa
Name

homeobox A cluster
Synonyms

Hox-1

Feature Type

complex/cluster/region
IDs

MGI:96169
NCBI Gene: 111336
Cluster Members

Hoxa1, Hoxa2, Hoxa3 ... (11 members)
Regulated by

Rr543, Rr449, Rr450 ... (6 regulatory regions)

Sequence Map

Genome coordinates not available from the current reference assembly.

Genetic Map

Chromosome 6, cytoband B3-C
Mapping Data

18 experiments

RFLP

3

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
20 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Find Mice (IMSR)

0 strains or lines available

Mice homozygous for mutations in multiple members of the cluster display a range of phenotypes including prenatal and postnatal lethality and developmental defects in the skeletal, reproductive nervous, cardiovascular, digestive, immune, glandular and renal/urinary systems.

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NCBI Gene

111336

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All nucleic 6

Genomic 6

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MGD-MRK-10814, MGD-MRK-10870

Summaries

All 68

Phenotypes 19
Earliest

J:7440 McGinnis W, et al., A homologous protein-coding sequence in Drosophila homeotic genes and its conservation in other metazoans. Cell. 1984 Jun;37(2):403-8
Latest

J:331393 Mohibi S, et al., Poly zinc finger protein ZFP14 suppresses lymphomagenesis and abnormal inflammatory response via the HOXA gene cluster. Biochim Biophys Acta Mol Basis Dis. 2023 Jan 1;1869(1):166587

Hoxa expression regulated by:

Feature	Feature Type	Location	Reference
Rr543, regulatory region 543	enhancer	Chr6:50650594-51173785	J:344244
Rr449, regulatory region 449	enhancer	Chr6:52130345-52130896	J:24362
Rr450, regulatory region 450	response element	Chr6:52130405-52130423	J:24362
Rr448, regulatory region 448	enhancer	Chr6:52138112-52140568	J:24362
Rr447, regulatory region 447	enhancer	Chr6:52140568-52141812	J:24362
Rr579, regulatory region 579	response element	Chr6, Syntenic	J:208763

Hoxa Cluster contains:

More Data for these features

Member	Feature Type	Location
Hoxa1, homeobox A1	protein coding gene	Chr6:52132573-52135299 (-)
Hoxa2, homeobox A2	protein coding gene	Chr6:52139397-52141811 (-)
Hoxa3, homeobox A3	protein coding gene	Chr6:52146042-52190316 (-)
Hoxa4, homeobox A4	protein coding gene	Chr6:52166662-52168683 (-)
Hoxa5, homeobox A5	protein coding gene	Chr6:52178768-52181437 (-)
Hoxa6, homeobox A6	protein coding gene	Chr6:52183268-52185702 (-)
Hoxa7, homeobox A7	protein coding gene	Chr6:52191471-52198757 (-)
Hoxa9, homeobox A9	protein coding gene	Chr6:52200077-52203169 (-)
Hoxa10, homeobox A10	protein coding gene	Chr6:52208177-52217658 (-)
Hoxa11, homeobox A11	protein coding gene	Chr6:52219086-52222784 (-)
Hoxa13, homeobox A13	protein coding gene	Chr6:52235833-52237865 (-)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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