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Defa1 Gene Detail
Summary
  • Symbol
    Defa1
  • Name
    defensin, alpha 1
  • Synonyms
    cryptdin-1, Defcr1
  • Feature Type
    protein coding gene
  • IDs
    MGI:94880
    NCBI Gene: 13216
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Genome coordinates not available from the current reference assembly.
  • Genetic Map
    Chromosome 8, Syntenic
  • Mapping Data
    16 experiments
Strain
Comparison
more
  • RFLP
    3
Homology
more
  • Human Ortholog
    DEFA1, defensin alpha 1
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DEFA1, defensin alpha 1
  • Synonyms
    DEF1, DEFA2, HNP-1, HP1, HP-1, MRS
  • Links
    NCBI Gene ID: 1667
    neXtProt AC: NX_P59665
    UniProt: P59665

  • Chr Location
    8p23.1; chr8:6977649-6980092 (-)  GRCh38
  • Human Ortholog
    DEFA1B, defensin alpha 1B
  • Synonyms
    HNP-1, HP1, HP-1
  • Links
    NCBI Gene ID: 728358
    neXtProt AC: NX_P59665
    UniProt: P59665

  • Chr Location
    8p23.1; chr8:6996766-6999198 (-)  GRCh38
  • Human Ortholog
    DEFA3, defensin alpha 3
  • Synonyms
    DEF3, HNP3, HNP-3, HP3, HP-3
  • Links
    NCBI Gene ID: 1668
    neXtProt AC: NX_P59666
    UniProt: P59666

  • Chr Location
    8p23.1; chr8:7015869-7018297 (-)  GRCh38
  • Human Ortholog
    DEFA5, defensin alpha 5
  • Synonyms
    DEF5, HD-5
  • Links
    NCBI Gene ID: 1670
    neXtProt AC: NX_Q01523
    UniProt: Q01523

  • Chr Location
    8p23.1; chr8:7055304-7056739 (-)  GRCh38
  • Human Ortholog
    DEFA6, defensin alpha 6
  • Synonyms
    DEF6, HD-6
  • Links
    NCBI Gene ID: 1671
    neXtProt AC: NX_Q01524
    UniProt: Q01524

  • Chr Location
    8p23.1; chr8:6924697-6926076 (-)  GRCh38
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    15
  • Tissues
    7
  • cDNA Data
    6
  • Literature Summary
    10
  • Other Mouse Links
    GEO
Sequences &
Gene Models
less
  • All Sequences
    7
  • RefSeq
    2
  • UniProt
    1
Representative SequencesLengthStrain/SpeciesFlank
genomic AF178043 GenBank | ENA | DDBJ | MGI Sequence Detail 617 129X1/SvJ ±  kb
transcript NM_010031 RefSeq | MGI Sequence Detail 427 Swiss albino  
polypeptide P11477 UniProt | EBI | MGI Sequence Detail 93 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    Genomic 1
    cDNA 8
    Primer pair 3
    Other 2

    Microarray probesets 1
Other
Accession IDs
less
MGD-MRK-8822
References
more
  • Summaries
    All 49
    Developmental Gene Expression 10
    Gene Ontology 6
  • Earliest
    J:10035 Ouellette AJ, et al., Localization of the cryptdin locus on mouse chromosome 8 [published erratum appears in Genomics 1992 Mar;12(3):626]. Genomics. 1989 Aug;5(2):233-9
  • Latest
    J:321983 Yu Y, et al., Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8(+/-) mouse model of ASD-like behavior. Nat Commun. 2022 Mar 3;13(1):1151
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory