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Igf1em1(cre/ERT2)Jtsym
Endonuclease-mediated Allele Detail
Summary
Symbol: Igf1em1(cre/ERT2)Jtsym
Name: insulin-like growth factor 1; endonuclease-mediated mutation 1, Jun Tsuyama
MGI ID: MGI:8434870
Synonyms: Igf1IRES-creER
Gene: Igf1  Location: Chr10:87694127-87772904 bp, + strand  Genetic Position: Chr10, 43.7 cM
Alliance: Igf1em1(cre/ERT2)Jtsym page
Mutation
origin
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Igf1em1(cre/ERT2)Jtsym expression driven by 1 gene
 
Mutation details: 

CRISPR/Cas9 genome editing technology was used to insert an IRES2 sequence and ERT2CreERT2 fusion protein in the 3' UTR of the gene. (J:387340)

Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Igf1 (mouse)
Summary of all recombinase alleles driven by Igf1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igf1 Mutation:  26 strains or lines available
References
Original:  J:387340 Tsuyama J, et al., Sustaining microglial reparative function enhances stroke recovery. Nature. 2026 May 13;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
09/15/2026
MGI 6.29 		The Jackson Laboratory