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Col8a2em1(cre/ERT2)Dgd
Endonuclease-mediated Allele Detail
Summary
Symbol: Col8a2em1(cre/ERT2)Dgd
Name: collagen, type VIII, alpha 2; endonuclease-mediated mutation 1, Diego G Ogando
MGI ID: MGI:8403703
Synonyms: Col8a2P2A-CreERT2
Gene: Col8a2  Location: Chr4:126180613-126208123 bp, + strand  Genetic Position: Chr4, 60.29 cM
Alliance: Col8a2em1(cre/ERT2)Dgd page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Mutation:    Insertion
 
Col8a2em1(cre/ERT2)Dgd expression driven by 1 gene
 
Mutation details: 

CRISPR/Cas-mediated targeting inserted a P2A self-cleaving sequence and inducible recombinase gene (cre/ERT2) after the stop codon. (J:385319)

Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Col8a2 (mouse)
Summary of all recombinase alleles driven by Col8a2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Col8a2 Mutation:  19 strains or lines available
References
Original:  J:385319 Yuan Y, et al., Generation of a Novel Col8a2(P2A-CreERT2) Mouse Line Enables Targeted Genetic Manipulation of Corneal Endothelial Cells and Modeling of Endothelial Decompensation. Genesis. 2026 Apr;64(2):e70047
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/14/2026
MGI 6.24 		The Jackson Laboratory