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Cdkn1aem1(cre/ERT)Hmeh
Endonuclease-mediated Allele Detail
Summary
Symbol: Cdkn1aem1(cre/ERT)Hmeh
Name: cyclin dependent kinase inhibitor 1A; endonuclease-mediated mutation 1, Hiruy S Meharena
MGI ID: MGI:8354833
Synonyms: Cdkn1aCreERT2
Gene: Cdkn1a  Location: Chr17:29309953-29319696 bp, + strand  Genetic Position: Chr17, 15.12 cM
Alliance: Cdkn1aem1(cre/ERT)Hmeh page
Mutation
origin
Strain of Origin:  C57BL/6NHsd
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Cdkn1aem1(cre/ERT)Hmeh expression driven by 1 gene
 
Mutation details: Using CRISPR/Cas9 technology, a CreER and 2PA sequence was inserted immediately downstream of the Cdkn1a promoter and upstream of the coding sequence. A sgRNA (5'-GACATCACCAGGATTGGACA-3') was used. (J:101977, J:387472)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cdkn1a (mouse)
Summary of all recombinase alleles driven by Cdkn1a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdkn1a Mutation:  64 strains or lines available
References
Original:  J:387472 Watson LA, et al., Persistent and transient senescent cells contribute to brain-barrier development. Cell. 2026 Jun 10;
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
06/16/2026
MGI 6.24 		The Jackson Laboratory