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Acta2tm1(cre/ERT2)Spdl
Targeted Allele Detail
Summary
Symbol: Acta2tm1(cre/ERT2)Spdl
Name: actin alpha 2, smooth muscle, aorta; targeted mutation 1, Stijn De Langhe
MGI ID: MGI:8310082
Synonyms: Acta2-Frt-STOP-FRT-CreERT2
Gene: Acta2  Location: Chr19:34218490-34232990 bp, - strand  Genetic Position: Chr19, 29.41 cM, cytoband C3
Alliance: Acta2tm1(cre/ERT2)Spdl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:340922
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Conditional ready, Inducible degradation, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Acta2tm1(cre/ERT2)Spdl expression driven by 1 gene
 
Mutation details: The CreERT2 cassette, preceded by a STOP codon and flanked by Frt sites, was inserted behind the ATG in the Acta2 locus. The STOP sequence contains PGKneo. (J:101977, J:340922)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Acta2 (mouse)
Summary of all recombinase alleles driven by Acta2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acta2 Mutation:  56 strains or lines available
References
Original:  J:340922 Lyu H, et al., Niche-mediated repair of airways is directed in an occupant-dependent manner. Cell Rep. 2022 Dec 20;41(12):111863
All:  3 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory