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Clec7aem1(cre)Jkpns
Endonuclease-mediated Allele Detail
Summary
Symbol: Clec7aem1(cre)Jkpns
Name: C-type lectin domain family 7, member a; endonuclease-mediated mutation 1, Jonathan Kipnis
MGI ID: MGI:8290442
Synonyms: Clec7a-P2A-iCreERT2
Gene: Clec7a  Location: Chr6:129438554-129449742 bp, - strand  Genetic Position: Chr6, 63.34 cM, cytoband F3
Alliance: Clec7aem1(cre)Jkpns page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Mutation:    Insertion
 
Clec7aem1(cre)Jkpns expression driven by 1 gene
 
Mutation details: CRISPR/Cas9 genome editing technology was used to insert a cassette containing a 2A-iCreERT2 construct before stop codon in the region between exon 5 and 3 UTR of the gene. (J:349784)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Clec7a (mouse)
Summary of all recombinase alleles driven by Clec7a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Clec7a Mutation:  25 strains or lines available
References
Original:  J:349784 Barclay KM, et al., An inducible genetic tool to track and manipulate specific microglial states reveals their plasticity and roles in remyelination. Immunity. 2024 Jun 11;57(6):1394-1412.e8
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory