About   Help   FAQ
Plxnd1tm1.1(flpo)Hze
Targeted Allele Detail
Summary
Symbol: Plxnd1tm1.1(flpo)Hze
Name: plexin D1; targeted mutation 1.1, Hongkui Zeng
MGI ID: MGI:8290424
Synonyms: Plxnd1-IRES2-dgFlpO
Gene: Plxnd1  Location: Chr6:115931772-115971966 bp, - strand  Genetic Position: Chr6, 53.72 cM
Alliance: Plxnd1tm1.1(flpo)Hze page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:260362
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Plxnd1tm1.1(flpo)Hze expression driven by 1 gene
 
Mutation details: The targeting vector contains, from 5' to 3', a partial Plxnd1 sequence spanning exon 1 through part of exon 2 up to (but not including) the endogenous stop codon,a T2A sequence, a flpO recombinase gene (a codon-optimized FLPe gene), a BHG polyA sequence, an AttB site, a PGK-neomycin cassette, an mRNA splice acceptor sequence, the 3' portion of the hygromycin gene (Hygro2) with SV40 polyA signal, and an AttP site. PhiC31-mediated recombination removed the AttB/AttP-flanked sequence and replaced it with the recombined AttB/AttP site (AttL). (J:260362)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Plxnd1 (mouse)
Summary of all recombinase alleles driven by Plxnd1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plxnd1 Mutation:  88 strains or lines available
References
Original:  J:260362 Daigle TL, et al., A suite of transgenic driver and reporter mouse lines with enhanced brain cell type targeting and functionality. Cell. 2018 Jul 12;174(2):465-480.e22
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory