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Irx3tm1(cre)Mpot
Targeted Allele Detail
Summary
Symbol: Irx3tm1(cre)Mpot
Name: Iroquois related homeobox 3; targeted mutation 1, Matthew J Potthoff
MGI ID: MGI:8288907
Synonyms: Irx3-Cre
Gene: Irx3  Location: Chr8:92525139-92528282 bp, - strand  Genetic Position: Chr8, 44.55 cM
Alliance: Irx3tm1(cre)Mpot page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:377847
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
 
Irx3tm1(cre)Mpot expression driven by 1 gene
    IRES sequence and the cre recombinase gene were inserted into the 3' UTR of exon 4. (J:377847)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Irx3 (mouse)
Summary of all recombinase alleles driven by Irx3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irx3 Mutation:  29 strains or lines available
References
Original:  J:377847 Sullivan AI, et al., Mice harboring the obesity-associated SNP rs1421085 exhibit increased body weight and reveal an IRX3 neuronal circuit regulating body weight. Mol Metab. 2025 Oct;100:102234
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory