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Gzmctm1.1(cre)Moli
Targeted Allele Detail
Summary
Symbol: Gzmctm1.1(cre)Moli
Name: granzyme C; targeted mutation 1.1, Ming Li
MGI ID: MGI:8270809
Synonyms: GzmctdTomato-T2A-iCre
Gene: Gzmc  Location: Chr14:56468898-56472113 bp, - strand  Genetic Position: Chr14, 28.19 cM
Alliance: Gzmctm1.1(cre)Moli page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:352601
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Recombinase, Reporter)
Mutation:    Insertion
 
Gzmctm1.1(cre)Moli expression driven by 1 gene
 
Mutation details: An IRES-tdTomato-T2A-Cre-frt-NEO-BGHpA-frt sequence was inserted into the Gzmc 3' UTR by homologous recombination in ES cells. Mice were bred to FLPeR mice to excise the NEO cassette. (J:352601)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gzmc (mouse)
Summary of all recombinase alleles driven by Gzmc.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gzmc Mutation:  16 strains or lines available
References
Original:  J:352601 Nixon BG, et al., Cytotoxic granzyme C-expressing ILC1s contribute to antitumor immunity and neonatal autoimmunity. Sci Immunol. 2022 Apr 8;7(70):eabi8642
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory