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Sostem1(cre/ERT2)Bwd
Endonuclease-mediated Allele Detail
Summary
Symbol: Sostem1(cre/ERT2)Bwd
Name: sclerostin; endonuclease-mediated mutation 1, Lynda F Bonewald
MGI ID: MGI:8264712
Gene: Sost  Location: Chr11:101853284-101857841 bp, - strand  Genetic Position: Chr11, 65.48 cM, cytoband D
Alliance: Sostem1(cre/ERT2)Bwd page
Mutation
origin
Strain of Origin:  C57BL/6NJ
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Sostem1(cre/ERT2)Bwd expression driven by 1 gene
 
Mutation details: A sgRNA (AGGCGCGGGCTCGCTCTAGT) was designed to insert a P2A self-cleaving peptide sequence (P2A) fused to a cre/ERT2 fusion gene (a Cre recombinase fused to a human estrogen receptor ligand binding domain) into the 3' UTR of the sclerostin (Sost) gene. (J:101977)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Sost (mouse)
Summary of all recombinase alleles driven by Sost.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sost Mutation:  29 strains or lines available
References
Original:  J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017;
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory