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Muc2em1.1(cre/ERT2)Cjl
Endonuclease-mediated Allele Detail
Summary
Symbol: Muc2em1.1(cre/ERT2)Cjl
Name: mucin 2; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
MGI ID: MGI:8261402
Gene: Muc2  Location: Chr7:141276583-141308428 bp, + strand  Genetic Position: Chr7, 87.1 cM, cytoband F5
Alliance: Muc2em1.1(cre/ERT2)Cjl page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:367194
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Epitope tag, Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Muc2em1.1(cre/ERT2)Cjl expression driven by 1 gene
 
Mutation details: CRISPR/cas9-mediated recombination inserted a construct containing mouse codon optimized 2xV5 epitope tag, T2a, and cre/ERT2 sequences in frame immediately before the stop codon. The open reading frame was followed by and FRT-flanked neo cassette. Flp-mediated recombination then removed the neo cassette. (J:367194)
Inheritance:    Not Specified
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Muc2 (mouse)
Summary of all recombinase alleles driven by Muc2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Muc2 Mutation:  86 strains or lines available
References
Original:  J:367194 Johnson NM, et al., Limitations to Understanding Intestinal Stem Cell Activity via Cre-Lox-Based Lineage Tracing. Cell Mol Gastroenterol Hepatol. 2022;14(6):1334-1337.e1
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory