Cdadc1<em2Boch> Endonuclease-mediated Allele Detail MGI Mouse (MGI:8261287)

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Cdadc1^em2Boch
Endonuclease-mediated Allele Detail

Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Summary

Symbol:	Cdadc1^em2Boch
Name:	cytidine and dCMP deaminase domain containing 1; endonuclease-mediated mutation 2, Matthias Bochtler
MGI ID:	MGI:8261287
Gene:	Cdadc1 Location: Chr14:59796837-59835408 bp, - strand Genetic Position: Chr14, 31.48 cM, cytoband C3
Alliance:	Cdadc1^em2Boch page

Mutation
origin

Strain of Origin:

C57BL/6JRj

Mutation
description

Allele Type:		Endonuclease-mediated (Null/knockout)
Mutation:		Intragenic deletion
		Mutation details: CRISPR/Cas9 technology generated a 17 bp (TACATCATACATGCGGA) deletion. This allele was generated by coinjecting sgRNA targeting Cdadc1 and Dctd and generates a double knock-out with the Dctd^em1Boch allele. (J:372389)

Phenotypes

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Cdadc1 Mutation:	29 strains or lines available

References

Original:	J:372389 Slyvka A, et al., Activity and structure of human (d)CTP deaminase CDADC1. Proc Natl Acad Sci U S A. 2025 May 13;122(19):e2424245122
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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