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Scn10aem1(icre)Itsu
Endonuclease-mediated Allele Detail
Summary
Symbol: Scn10aem1(icre)Itsu
Name: sodium channel, voltage-gated, type X, alpha; endonuclease-mediated mutation 1, Isao Tsuneyoshi
MGI ID: MGI:8261239
Synonyms: NaV1.8-iCre, NaV1.8iCre
Gene: Scn10a  Location: Chr9:119437522-119548388 bp, - strand  Genetic Position: Chr9, 71.33 cM, cytoband distal
Alliance: Scn10aem1(icre)Itsu page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Scn10aem1(icre)Itsu expression driven by 1 gene
 
Mutation details: CRISPR/cas9-mediated recombination inserted a P2A-iCre-rabbit globin polyadenylation sequence after the termination codon. (J:365780)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Scn10a (mouse)
Summary of all recombinase alleles driven by Scn10a.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Scn10a Mutation:  107 strains or lines available
References
Original:  J:365780 Maruta T, et al., Comparison of Nocifensive Behavior in Na(V)1.7-, Na(V)1.8-, and Na(V)1.9-Channelrhodopsin-2 Mice by Selective Optogenetic Activation of Targeted Sodium Channel Subtype-Expressing Afferents. J Neurosci Res. 2024 Oct;102(10):e25386
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory