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Cd274em1(cre/ERT2)Caic
Endonuclease-mediated Allele Detail
Summary
Symbol: Cd274em1(cre/ERT2)Caic
Name: CD274 antigen; endonuclease-mediated mutation 1, Cheguo Cai
MGI ID: MGI:8261056
Synonyms: PD-L1-, PD-L1CreERT2-2A-tdTomato-WERP-pA
Gene: Cd274  Location: Chr19:29344855-29365495 bp, + strand  Genetic Position: Chr19, 23.88 cM, cytoband C2
Alliance: Cd274em1(cre/ERT2)Caic page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Null/knockout, Recombinase, Reporter)
Inducer:    tamoxifen
Mutations:    Insertion, Intragenic deletion
 
Cd274em1(cre/ERT2)Caic expression driven by 1 gene
 
Mutation details: A construct containing a kozak sequence, cre/ERT2-21-tdTomato cassette, WERP, and pA sequence was inserted in place of the coding region of exon 2. (J:366226)
Inheritance:    Not Specified
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cd274 (mouse)
Summary of all recombinase alleles driven by Cd274.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd274 Mutation:  37 strains or lines available
References
Original:  J:366226 Wang R, et al., Programmed Cell Death Ligand 1 Is Enriched in Mammary Stem Cells and Promotes Mammary Development and Regeneration. Front Cell Dev Biol. 2021;9:772669
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory