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Spdefem1(icre)Wopg
Endonuclease-mediated Allele Detail
Summary
Symbol: Spdefem1(icre)Wopg
Name: SAM pointed domain containing ets transcription factor; endonuclease-mediated mutation 1, Woo-ping Ge
MGI ID: MGI:8261039
Synonyms: Spdef-Cre
Gene: Spdef  Location: Chr17:27933326-27947929 bp, - strand  Genetic Position: Chr17, 14.59 cM, cytoband B1
Alliance: Spdefem1(icre)Wopg page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Spdefem1(icre)Wopg expression driven by 1 gene
    CRISPR/cas9-mediated recombination inserted an icre-WPRE-pA cassette adjacent to the start codon. (J:374541)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Spdef (mouse)
Summary of all recombinase alleles driven by Spdef.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Spdef Mutation:  17 strains or lines available
References
Original:  J:374541 Zhang T, et al., The subcommissural organ regulates brain development via secreted peptides. Nat Neurosci. 2024 Jun;27(6):1103-1115
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory