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Gcgem1(cre)Xug
Endonuclease-mediated Allele Detail
Summary
Symbol: Gcgem1(cre)Xug
Name: glucagon; endonuclease-mediated mutation 1, University of Tsukuba Laboratory Animal Resource Center
MGI ID: MGI:8260934
Synonyms: GcgCre, GcgfrtCre
Gene: Gcg  Location: Chr2:62304874-62313994 bp, - strand  Genetic Position: Chr2, 35.85 cM
Alliance: Gcgem1(cre)Xug page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Conditional ready, Recombinase)
Mutation:    Insertion
 
Gcgem1(cre)Xug expression driven by 1 gene
 
Mutation details: CRISPR/cas9-mediated recombination inserted an IRES-F3-Frt-WPRE-pA-Cre-Frt-F3 cassette into the 3' UTR in inverse orientation. Flp-mediated recombination inverts the cassette allowing expression of the cre. (J:364895)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Gcg (mouse)
Summary of all recombinase alleles driven by Gcg.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gcg Mutation:  35 strains or lines available
References
Original:  J:364895 Huang Y, et al., Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells. Elife. 2024 Nov 7;13
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory