Pax1<em1(cre/ERT2)Mbgr> Endonuclease-mediated Allele Detail MGI Mouse (MGI:8259258)

Pax1^{em1(cre/ERT2)Mbgr}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Pax1^{em1(cre/ERT2)Mbgr}
Name:	paired box 1; endonuclease-mediated mutation 1, Matthew B Greenblatt
MGI ID:	MGI:8259258
Synonyms:	Pax1-creER^T2
Gene:	Pax1 Location: Chr2:147203850-147216972 bp, + strand Genetic Position: Chr2, 72.63 cM
Alliance:	Pax1^{em1(cre/ERT2)Mbgr} page

Mutation
origin

Strain of Origin:

C57BL/6

Mutation
description

Allele Type:

Endonuclease-mediated (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Pax1^{em1(cre/ERT2)Mbgr} expression driven by 1 gene

Mutation details: CRISPR/cas9-mediated recombination inserted a cre/ERT2-rBG-pA into exon 1 adjacent to the untranslated region. (J:347266)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Pax1 (mouse) Summary of all recombinase alleles driven by Pax1. Alliance mouse Pax1 gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Pax1 Mutation:	27 strains or lines available

References

Original:	J:347266 Sun J, et al., A vertebral skeletal stem cell lineage driving metastasis. Nature. 2023 Sep;621(7979):602-609
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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