About   Help   FAQ
Esr1tm1.1(flpo)Xhx
Targeted Allele Detail
Summary
Symbol: Esr1tm1.1(flpo)Xhx
Name: estrogen receptor 1 (alpha); targeted mutation 1.1, Xiao-Hung Xu
MGI ID: MGI:8257376
Synonyms: Esr1FlpO
Gene: Esr1  Location: Chr10:4561989-4955633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Alliance: Esr1tm1.1(flpo)Xhx page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:368634
Parent Cell Line:  JM8A3 (ES Cell)
Strain of Origin:  C57BL/6N-Atm1Brd
Mutation
description
Allele Type:    Targeted (Conditional ready, Null/knockout, Recombinase, Reporter)
Mutation:    Insertion
 
Esr1tm1.1(flpo)Xhx expression driven by 1 gene
 
Mutation details: A construct contain a floxed stop cassette, flpo-2A-EGFP-polyA cassette, and FRT-flanked pgk-neo cassette was inserted in exon 2 just after the start codon. Flp-mediated recombination removed the neo cassette. (J:368634)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Esr1 (mouse)
Summary of all recombinase alleles driven by Esr1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:  69 strains or lines available
References
Original:  J:368634 Zha X, et al., Estrogen signaling in the ventromedial hypothalamus is required for the development of aggression circuitry in male mice. Curr Biol. 2025 Jun 9;35(11):2684-2696.e6
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory