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Tcf21tm1(icre/ERT2)Bcgen
Targeted Allele Detail
Summary
Symbol: Tcf21tm1(icre/ERT2)Bcgen
Name: transcription factor 21; targeted mutation 1, Biocytogen LLC
MGI ID: MGI:8256890
Synonyms: Tcf21-CreER
Gene: Tcf21  Location: Chr10:22693162-22696042 bp, - strand  Genetic Position: Chr10, 10.33 cM
Alliance: Tcf21tm1(icre/ERT2)Bcgen page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:373634
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Inducer:    tamoxifen
Mutation:    Insertion
 
Tcf21tm1(icre/ERT2)Bcgen expression driven by 1 gene
 
Mutation details: An icre/ERT2-WPRE-pA sequence cassette was inserted downstream of the 5UTR via homologous recombination. (J:308681)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tcf21 (mouse)
Summary of all recombinase alleles driven by Tcf21.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tcf21 Mutation:  19 strains or lines available
References
Original:  J:373634 Huang D, et al., ANGPTL2-containing small extracellular vesicles from vascular endothelial cells accelerate leukemia progression. J Clin Invest. 2021 Jan 4;131(1)
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory