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Ly6g6eem1.1(cre)Cems
Endonuclease-mediated Allele Detail
Summary
Symbol: Ly6g6eem1.1(cre)Cems
Name: lymphocyte antigen 6 family member G6E; endonuclease-mediated mutation 1.1, Mark S Cembrowski
MGI ID: MGI:8255250
Synonyms: Ly6g6e-IRES-Cre
Gene: Ly6g6e  Location: Chr17:35295878-35297780 bp, + strand  Genetic Position: Chr17, 18.59 cM, cytoband B2
Alliance: Ly6g6eem1.1(cre)Cems page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:367802
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6J)F1
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase)
Mutation:    Insertion
 
Ly6g6eem1.1(cre)Cems expression driven by 1 gene
 
Mutation details: CRISPR/cas9-mediated recombination inserted an IRES-cre-FRT-pgk-neo-FRT cconstruct immediately after the stop codon. Flp-mediated recombination removed the pgk-neo cassette. (J:367802)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Ly6g6e (mouse)
Summary of all recombinase alleles driven by Ly6g6e.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ly6g6e Mutation:  17 strains or lines available
Notes
CRISPR targeting was done in G1 ES cells
References
Original:  J:367802 Kinman AI, et al., Atypical hippocampal excitatory neurons express and govern object memory. Nat Commun. 2025 Feb 12;16(1):1195
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory