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Etv2em1(icre/ERT2)Susa
Endonuclease-mediated Allele Detail
Summary
Symbol: Etv2em1(icre/ERT2)Susa
Name: ets variant 2; endonuclease-mediated mutation 1, Saulius Sumanas
MGI ID: MGI:8253474
Synonyms: Etv2T2A-iCreERT2
Gene: Etv2  Location: Chr7:30333041-30335277 bp, - strand  Genetic Position: Chr7, 18.92 cM, cytoband A3
Alliance: Etv2em1(icre/ERT2)Susa page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Mutation:    Insertion
 
Etv2em1(icre/ERT2)Susa expression driven by 1 gene
 
Mutation details: CRISPR/cas9-mediated recombination inserted a T2A-icre/ERT2 cassette in place of the TAA termination codon at the 3' end of the gene. The targeting construct also contained two silent mutations replacing two GAT codons (D324 and D325) with synonymous GAC codons. (J:369408)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Etv2 (mouse)
Summary of all recombinase alleles driven by Etv2.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Etv2 Mutation:  11 strains or lines available
References
Original:  J:369408 Metikala S, et al., Integration of vascular progenitors into functional blood vessels represents a distinct mechanism of vascular growth. Dev Cell. 2022 Mar 28;57(6):767-782.e6
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory