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Tph1em1(cre/ERT2)Heno
Endonuclease-mediated Allele Detail
Summary
Symbol: Tph1em1(cre/ERT2)Heno
Name: tryptophan hydroxylase 1; endonuclease-mediated mutation 1, Hideki Enomoto
MGI ID: MGI:8253358
Synonyms: Tph1CreERT2
Gene: Tph1  Location: Chr7:46294065-46321961 bp, - strand  Genetic Position: Chr7, 30.43 cM
Alliance: Tph1em1(cre/ERT2)Heno page
Mutation
origin
Strain of Origin:  C57BL/6N
Mutation
description
Allele Type:    Endonuclease-mediated (Inducible, Recombinase)
Mutation:    Insertion
 
Tph1em1(cre/ERT2)Heno expression driven by 1 gene
 
Mutation details: CRISPR/cas9-mediated recombination inserted a cre/ERT2 cassette just upstream of the initiation codon. (J:369506)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tph1 (mouse)
Summary of all recombinase alleles driven by Tph1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tph1 Mutation:  43 strains or lines available
References
Original:  J:369506 Sesotyosari SL, et al., The long-term survival of enteroendocrine cells depends on their subtype and is linked to peripheral sensory innervation. Dev Growth Differ. 2025 May;67(4):205-214
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory