Prl<em1(cre/ERT2)Wpjz> Endonuclease-mediated Allele Detail MGI Mouse (MGI:8253339)

Prl^{em1(cre/ERT2)Wpjz}
Endonuclease-mediated Allele Detail

Summary

Symbol:	Prl^{em1(cre/ERT2)Wpjz}
Name:	prolactin; endonuclease-mediated mutation 1, Weiping Zhang
MGI ID:	MGI:8253339
Synonyms:	Prl^CreER
Gene:	Prl Location: Chr13:27241553-27249187 bp, + strand Genetic Position: Chr13, 12.25 cM
Alliance:	Prl^{em1(cre/ERT2)Wpjz} page

Mutation
origin

Strain of Origin:

C57BL/6

Mutation
description

Allele Type:

Endonuclease-mediated (Inducible, Recombinase)

Inducer:

tamoxifen

Mutation:

Insertion

Prl^{em1(cre/ERT2)Wpjz} expression driven by 1 gene

Mutation details: CRISPR/cas9-mediated recombination inserted a P2A-cre/ERT2 cassette at the end of exon 5 upstream of the 3' UTR. (J:369926)

Recombinase
activity

Activity:	Tissue activity of this recombinase allele
Driver:	Prl (mouse) Summary of all recombinase alleles driven by Prl. Alliance mouse Prl gene page

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Prl Mutation:	26 strains or lines available

References

Original:	J:369926 Han Q, et al., ZBTB20 Regulates Prolactin Expression and Lactotrope Function in Adult Mice. Endocrinology. 2022 Oct 23;163(12)
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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