About   Help   FAQ
Wif1em1(cre/ERT2)Tchn
Endonuclease-mediated Allele Detail
Summary
Symbol: Wif1em1(cre/ERT2)Tchn
Name: Wnt inhibitory factor 1; endonuclease-mediated mutation 1, Ting Chen
MGI ID: MGI:8250831
Synonyms: Wif1-CreER
Gene: Wif1  Location: Chr10:120869909-120936547 bp, + strand  Genetic Position: Chr10, 68.98 cM
Alliance: Wif1em1(cre/ERT2)Tchn page
Mutation
origin
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Endonuclease-mediated (Recombinase, Reporter)
Inducer:    tamoxifen
Mutation:    Insertion
 
Wif1em1(cre/ERT2)Tchn expression driven by 1 gene
 
Mutation details: An sgRNA (gagaaggtcctgagcacca) was designed to target the sequence near the ATG start codon of the Wnt inhibitory factor 1 (Wif1) gene for insertion of a cre/ERT2 fusion gene (containing a cre recombinase fused to a human estrogen receptor ligand binding domain) followed by a viral 2A oligopeptide (T2A) sequence to mediate ribosomal skipping, enhanced green fluorescent protein (EGFP) sequence, and a polyadenylation signal. (J:101977, J:372885)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Wif1 (mouse)
Summary of all recombinase alleles driven by Wif1.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Wif1 Mutation:  33 strains or lines available
References
Original:  J:372885 Chen D, et al., Fibroblast bioelectric signaling drives hair growth. Cell. 2025 Sep 18;188(19):5175-5193.e21
All:  2 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
10/07/2025
MGI 6.24 		The Jackson Laboratory